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Empty follicle syndrome

MedGen UID:
730227
•Concept ID:
C1328577
•
Disease or Syndrome
SNOMED CT: Empty follicle syndrome (426958002)

Professional guidelines

PubMed

Risk factors, management, and future fertility of empty follicle syndrome: a retrospective study with real-world data.
Luo Z, Xu S, Hao G
Front Endocrinol (Lausanne) 2024;15:1424837. Epub 2024 Jul 11 doi: 10.3389/fendo.2024.1424837. PMID: 39055059Free PMC Article
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved.
Matorras R, Aparicio V, Corcostegui B, Prieto B, Mendoza R, Ramón O, Gomez-Picado O, Exposito A
Reprod Biomed Online 2014 Nov;29(5):634-9. Epub 2014 Aug 12 doi: 10.1016/j.rbmo.2014.07.020. PMID: 25263264

Recent clinical studies

Etiology

Double HCG trigger improves recovery of oocytes in women with a paucifollicular response to ovarian stimulation: A pilot study.
Tesarik J, Galán-Lázaro M, Mendoza N, Mendoza-Tesarik R
Int J Gynaecol Obstet 2022 Apr;157(1):149-153. Epub 2021 Jun 7 doi: 10.1002/ijgo.13735. PMID: 33969486
Empty follicle syndrome: Frequency and probable causes in Pakistani Population.
Jehan S, Iram Z, Syed S
J Pak Med Assoc 2020 Sep;70(9):1538-1542. doi: 10.5455/JPMA.18623. PMID: 33040104
Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved.
Matorras R, Aparicio V, Corcostegui B, Prieto B, Mendoza R, Ramón O, Gomez-Picado O, Exposito A
Reprod Biomed Online 2014 Nov;29(5):634-9. Epub 2014 Aug 12 doi: 10.1016/j.rbmo.2014.07.020. PMID: 25263264
In vitro maturation for patients with repeated in vitro fertilization failure due to "oocyte maturation abnormalities".
Hourvitz A, Maman E, Brengauz M, Machtinger R, Dor J
Fertil Steril 2010 Jul;94(2):496-501. Epub 2009 Jul 8 doi: 10.1016/j.fertnstert.2009.03.040. PMID: 19589517
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817

Diagnosis

Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida.
Sun L, Tong K, Liu W, Tian Y, Liu D, Huang G, Li J
Reprod Biomed Online 2023 May;46(5):847-855. Epub 2023 Jan 16 doi: 10.1016/j.rbmo.2023.01.010. PMID: 36931917
A novel mutation in ZP3 causes empty follicle syndrome and abnormal zona pellucida formation.
Zhang D, Zhu L, Liu Z, Ren X, Yang X, Li D, Luo Y, Peng X, Zhou X, Jia W, Hou M, Li Z, Jin L, Zhang X
J Assist Reprod Genet 2021 Jan;38(1):251-259. Epub 2020 Nov 2 doi: 10.1007/s10815-020-01995-0. PMID: 33140178Free PMC Article
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Unique patient issues: early interventions and management.
Combelles C
Semin Reprod Med 2012 Jun;30(3):243-52. Epub 2012 May 14 doi: 10.1055/s-0032-1311527. PMID: 22585636
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817

Therapy

Unexpected repeat immature oocyte response after IVF stimulation: a case report.
Mishra V, Chirumamilla L
Gynecol Endocrinol 2018 Feb;34(2):100-102. Epub 2017 Aug 29 doi: 10.1080/09513590.2017.1369514. PMID: 28850271
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved.
Matorras R, Aparicio V, Corcostegui B, Prieto B, Mendoza R, Ramón O, Gomez-Picado O, Exposito A
Reprod Biomed Online 2014 Nov;29(5):634-9. Epub 2014 Aug 12 doi: 10.1016/j.rbmo.2014.07.020. PMID: 25263264
Can in vitro fertilization cycles be salvaged by repeat administration of intramuscular human chorionic gonadotropin the day after failed injection?
Reichman DE, Greenwood E, Meyer L, Kligman I, Rosenwaks Z
Fertil Steril 2012 Sep;98(3):671-4. Epub 2012 Jul 4 doi: 10.1016/j.fertnstert.2012.05.050. PMID: 22769734
In vitro maturation for patients with repeated in vitro fertilization failure due to "oocyte maturation abnormalities".
Hourvitz A, Maman E, Brengauz M, Machtinger R, Dor J
Fertil Steril 2010 Jul;94(2):496-501. Epub 2009 Jul 8 doi: 10.1016/j.fertnstert.2009.03.040. PMID: 19589517

Prognosis

Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Unique patient issues: early interventions and management.
Combelles C
Semin Reprod Med 2012 Jun;30(3):243-52. Epub 2012 May 14 doi: 10.1055/s-0032-1311527. PMID: 22585636
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817
Predicting empty follicle syndrome.
Ndukwe G, Thornton S, Fishel S, Dowell K, al-Hassan S, Hunter A
Fertil Steril 1996 Nov;66(5):845-7. PMID: 8893699
Empty follicle syndrome.
Coulam CB, Bustillo M, Schulman JD
Fertil Steril 1986 Dec;46(6):1153-5. doi: 10.1016/s0015-0282(16)49898-5. PMID: 3781029

Clinical prediction guides

Zona pellucida glycoproteins: Relevance in fertility and development of contraceptive vaccines.
Gupta SK
Am J Reprod Immunol 2023 Feb;89(2):e13535. Epub 2022 Mar 15 doi: 10.1111/aji.13535. PMID: 35249246
Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
Double HCG trigger improves recovery of oocytes in women with a paucifollicular response to ovarian stimulation: A pilot study.
Tesarik J, Galán-Lázaro M, Mendoza N, Mendoza-Tesarik R
Int J Gynaecol Obstet 2022 Apr;157(1):149-153. Epub 2021 Jun 7 doi: 10.1002/ijgo.13735. PMID: 33969486
Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved.
Matorras R, Aparicio V, Corcostegui B, Prieto B, Mendoza R, Ramón O, Gomez-Picado O, Exposito A
Reprod Biomed Online 2014 Nov;29(5):634-9. Epub 2014 Aug 12 doi: 10.1016/j.rbmo.2014.07.020. PMID: 25263264
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817

Recent systematic reviews

A systematic review and standardized clinical validity assessment of genes involved in female reproductive failure.
Volozonoka L, Miskova A, Kornejeva L, Kempa I, Bargatina V, Gailite L
Reproduction 2022 Apr 22;163(6):351-363. doi: 10.1530/REP-21-0486. PMID: 35451369Free PMC Article
Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
Empty follicle syndrome: the reality of a controversial syndrome, a systematic review.
Stevenson TL, Lashen H
Fertil Steril 2008 Sep;90(3):691-8. Epub 2007 Nov 26 doi: 10.1016/j.fertnstert.2007.07.1312. PMID: 18023430

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